The X-Men head west, founding a new home for all mutants in San Francisco! But they soon find themselves tangling with Magneto, Sentinels, and the all-new Hellfire Cult! Then, heartsick over losing Kitty Pryde, Colossus looks for something to stop his pain...and finds a nightmare from his past! Plus, Angel and the Beast gather the most unique minds on Earth to jump-start the mutant race, even as Emma Frost forges a dark alliance. Finally, who are the Sisterhood? How can they be led by Cyclops' late wife Madelyne Pryor - and why is Psylocke on their side?! Things get ugly for the X-Men as Eisner award-winner Matt Fraction turns up the heat! COLLECTING: Uncanny X-Men (1963) 500-511; Uncanny X-Men Annual (2006) 2; material from X-Men Unlimited (2004) 9, X-Men : Divided We Stand 1