After everything that he has been through, Omari can't even see himself in another relationship. Just the thought of Simone Campbell makes him turn away from any chick. Whether it's the baddest bitch or a foreign chick, he'll pass. But then "she" came into his life and that all changed. He's ready to live and love again, and she just might be the one. That is, if Simone doesn't ruin it like she has everything else in his life. Simone and her wicked, deadly ways are back. But she isn't still that devious side bitch that's obsessed with Omari Sutton. Now, she's obsessed with staying out of prison. However, one glimpse of Omari and his new leading lady causes her insanity to resurface. Little does she know, Detective Keisha Howard is just as obsessed as she is and won't sleep until she tracks down Simone to ensure that she pays for all of her murderous ways.

In Secrets of a Side Bitch 4, every lie, trick, and murder is laid out on the table, and karma begins to take its revenge on some, while new life begins for others.