Plagued with a rare disease that prevents him from recognizing faces, Billy carries a photograph in his pocket that is his only way of identifying his next target. Killing is in Billy's bloodline, as a member of Philadelphia's dangerous Farren crime family.

While Billy stalks Philadelphia, Detective Kevin Byrne is assigned to a series of bizarre home-invasion cases and is joined by his former partner-turned-assistant district attorney, Jessica Balzano. Their investigations circle Byrne's childhood neighborhood of Devil's Pocket, and they find themselves revisiting a crime from Byrne's past that has haunted him for decades. What Byrne witnessed as a child in Devil's Pocket jeopardizes the Farren family--which makes him the next target on Billy's hit list.

A multigenerational story of hardship, guilt, and redemption, Shutter Man is Byrne and Balzano's most tense and personal case to date.